Does ibuprofen have an expiration date and how long do they last? I have some pills that I have from a recent surgery from almost a year ago. And was kinda scare to take them again because they were old. Does Ibuprofen expire? Every medicine has a specific expiry date, which is marked for a reason. It is printed on the box in order to protect you from damaging your body and to cause the awareness about the reduced effectiveness of medicine in the body after the expiry date. ok, went to askjeeves.com and got my question answered..good to know, in MOST drugs cases, they do not harm you are really degrade that much. As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. What does a medicine’s expiration date mean?. and you reach for your bottle of ibuprofen and find that it expired last year, chances are high that the medicine still has retained most of its potency. However, it is still advisable to replace medicines that have expired years ago with a new supply to be sure you are using the most up-to-date product with the most up-to-date instructions. We do not recommend that Advil® be used after the expiration date. All of our products are assigned an expiration date, which is based upon extensive stability studies. Consumers can use expired ibuprofen, but the potency of ibuprofen cannot be guaranteed by the manufacturer after the expiration date. Many medications are safe for use up to one year after they expire, but it varies with environmental conditions, according to Drugs.com.